Antimicrobial and Antioxidant Role of the Aerial Parts of Aconitum violaceum

Abstract. In the current studies, crude and subsequent fractions of Aconitum violaceum aerial parts were screened for their toxicity, antimicrobial effects as well antioxidant potential. Phytochemically, plant is enriched in alkaloids alongside anthraquinones (present ethyl acetate fraction (AV3) saponins (detected chloroform (AV2). Brine shrimp lethality assay, AV3 was most potent (59 %) killing Artemia naupili larvae at a dose 1000 µg/mL. exhibited strongest effect against bacteria E. coli (80 S. flexneri (76 tested fungi, A. niger (86 respectively. However, (AV2) effective (almost 90 antifungal C. albicans. Overall, strong activity observed with IC50 values 120.04 ± 0.4 µg/mL (65.4 0.01 standard) DPPH 125.1 0.3 (2.0 0.03 ABTS free radical assays. showed promising inhibition acetylcholinesterase (AChE) 70 0.8 % butyrylcholinesterase (BChE) 57 0.2 100 thus confirming invitro cholinesterase inhibitory effect. The overall results indicated biological potential obtained form possible new therapeutic source could be formulated from its pure isolates.
 
 Resumen.